As its name indicates, CPW forms the western edge of Central Park. It also forms the eastern boundary of the Upper West Side. It runs 51 blocks from Columbus Circle (at 59th Street, or Central Park South) to Frederick Douglass Circle (at 110th Street, or Cathedral Parkway). The gates into Central Park along its western edge are: Merchants Gate at 59th Street, Women's Gate at 72nd, Naturalists Gate at 77th, Hunters Gate at 81st, Mariners Gate at 85th, Gate of all Saints at 96th, Boys Gate at 100th, and Strangers Gate at 106th. Central Park West's expensive housing rivals that of Fifth Avenue on the Upper East Side.

South of Columbus Circle, in Midtown, CPW becomes Eighth Avenue. North of Frederick Douglass Circle, in Harlem, it is alternately known as Eighth Avenue or Frederick Douglass Boulevard. Unlike many Manhattan avenues, CPW has traffic running in two directions. The IND Eighth Avenue Line runs under the avenue, serving local stations.